Regulating macrophage phenotypes with IL4I1-mimetic nanoparticles in IDD treatment.

Abstract excerpt

Intervertebral disc degeneration (IDD) is a degenerative spinal condition characterized by disc structural damage, narrowing of joint spaces, and nerve root compression, significantly reducing patients' quality of life. To address this challenge, a novel therapeutic strategy was developed using cellulose supramolecular hydrogel as a carrier to deliver IL4I1-modified MΦ membrane biomimetic nanoparticles...

Topics

• Animals
• Intervertebral Disc Degeneration
• Nanoparticles
• Macrophages
• Mice
• Hydrogels
• Biomimetic Materials