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Article

Cryo-EM structure of Nipah virus RNA polymerase complex.

Science advances - 13 Dec 2024

Wang Yiru, Zhao Lixia, Zhang Yi, Wang Yuhan, Tang Jiao, Liu Simiao, Gao Huihan, Zhang Xiaoxiao, Zinzula Luca, Kornberg Roger D, Zhang Heqiao

Abstract excerpt

Nipah virus, a member of the Paramyxoviridae family, is a highly pathogenic nonsegmented, negative-sense RNA virus (nsNSV) which causes severe neurological and respiratory illnesses in humans. There are no available drugs or vaccines to combat this virus. A complex of large polymerase protein (L) and phosphoprotein (P) of Nipah virus supports replication and transcription and affords a target for antiviral drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39661676
DOI: 10.1126/sciadv.adr7116
PMCID: PMC11633731

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