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Structural and functional analysis of the Nipah virus polymerase complex

20 Jan 2025

Abstract excerpt

Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans. The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a promising drug target. We determined the cryoelectron microscopy (cryo-EM) structure of the NiV polymerase complex, comprising the large protein (L) and phosphoprotein (P), and performed structural, biophysical, and in-depth functional...

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PMID: 39837328
DOI: 10.1016/j.cell.2024.12.021

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