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Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development

6 Mar 2025

Abstract excerpt

Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disruption results in lifelong metabolic consequences stemming from reduced β cell development. We show evidence for the existence of a similar program in humans and identify specific fungi and bacteria that are...

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PMID: 40048508
DOI: 10.1126/science.adn0953

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