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Article

Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner

1 Feb 2023

Abstract excerpt

Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient ( TCRδ −/− ) dams display an increase in first-breath-induced inflammation, with a pulmonary milieu selectively enriched in type 2 cytokines and type 2-polarized immune cells, when compared...

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PMID: 36787741
DOI: 10.1016/j.celrep.2023.112074

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