Article
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.
Nature microbiology - 22 Aug 2016
Livanos Alexandra E, Greiner Thomas U, Vangay Pajau, Pathmasiri Wimal, Stewart Delisha, McRitchie Susan, Li Huilin, Chung Jennifer, Sohn Jiho, Kim Sara, Gao Zhan, Barber Cecily, Kim Joanne, Ng Sandy, Rogers Arlin B, Sumner Susan, Zhang Xue-Song, Cadwell Ken, Knights Dan, Alekseyenko Alexander, Bäckhed Fredrik, Blaser Martin J
Abstract excerpt
The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either...
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