Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

5 Mar 2025

Abstract excerpt

Paternal lifestyle and environmental exposures can alter epigenetic changes in sperm and play a critical role in the offspring's future health, yet the underlying mechanisms remain elusive. The present study established a model of paternal obesity and found that the increased levels of H3K27me3 in sperm persist into the 8-cell embryo stage, resulting in a transgenerational decrease of Manf, which causes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to Epigenetics and DNA Methylation
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40041941
DOI: 10.1002/advs.202415956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female OffspringPMID 40041941Read ↗

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspringSemantic proximity Read ↗

Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunctionSemantic proximity Read ↗

Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunctionSemantic proximity Read ↗

Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring healthSemantic proximity Read ↗

Paternal obesity induces epigenetic aberrations and gene expression changes in placenta and fetusSemantic proximity Read ↗

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposureSemantic proximity Read ↗

Maternal obesity and diabetes may cause DNA methylation alteration in the spermatozoa of offspring in miceSemantic proximity Read ↗

Could parental high-fat intake program the reproductive health of male offspring? A reviewSemantic proximity Read ↗

Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular compositionSemantic proximity Read ↗

Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular compositionSemantic proximity Read ↗

Pregestational diet transition to normal-fat diet avoids the deterioration of pancreatic β-cell function in male offspring induced by maternal high-fat diet.Semantic proximity Read ↗

Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.