Article

Origin of Eukaryotic Plasmalogen Biosynthesis by Horizontal Gene Transfer from Myxobacteria

2025-10-10

Abstract excerpt

Plasmalogens, a unique class of membrane lipids defined by a distinctive vinyl ether bond, are critical for human health, with their altered levels linked to various diseases. Despite their importance, their origin and evolutionary history remain enigmatic. Here, we uncover the evolutionary history of the aerobic plasmalogen biosynthesis pathway in eukaryotes, focusing on the four essential enzymes responsible for...

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Literature Corpus work: 2f1708ae-dcd7-5745-af4c-583b0bc4f947
DOI: 10.1101/2025.10.10.681575

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