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Article

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease

1 Apr 2022

Abstract excerpt

Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson's disease (PD) pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct relevance to dopamine neuron survival through augmentation of PGC-1α-dependent mitochondrial biogenesis. Notably, knockout of PARIS attenuates dopaminergic neurodegeneration in mouse models, indicating that interventions that prevent...

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PMID: 35363524
DOI: 10.1126/sciadv.abh1824

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