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Article

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice.

GeroScience - 1 Aug 2025

Ferreira-Marques Marisa, Carmo-Silva Sara, Pereira Joana, Botelho Mariana, Nóbrega Clévio, López-Otín Carlos, de Almeida Luís Pereira, Aveleira Célia A, Cavadas Cláudia

Abstract excerpt

The hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40011349
DOI: 10.1007/s11357-025-01574-0
PMCID: PMC12397475

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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