Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults

Abstract excerpt

Background Calcific aortic valve disease (CAVD), and ensuing severe aortic stenosis (AS), is the foremost valvular disorder of aging, yet preventive therapies are lacking. A better understanding of the molecular underpinnings of aortic valve calcification (AVC) is necessary to develop pharmacologic interventions. Methods and Results We undertook large‐scale plasma proteomics in a cohort study of adults ≥65 years...

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