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Article

Exploration of Genetic Liability to Insomnia and Substance Use Disorders in Patients With Bipolar Disorder.

Bipolar disorders - 1 Jun 2025

Melhuish Beaupre Lindsay M, Coombes Brandon J, Batzler Anthony, Sanchez-Ruiz Jorge A, Kolla Bhanu Prakash, Romo-Nava Francisco, Pazdernik Vanessa, Jenkins Gregory, Waller T Cameron, Skime Michelle, McElroy Susan L, Frye Mark A, Biernacka Joanna M

Abstract excerpt

BACKGROUND: Insomnia and substance use disorders (SUD) are common comorbidities of bipolar disorder (BD). Genome-wide association studies (GWAS) have uncovered shared genetic contributions to insomnia and BD as well as SUDs and BD. Electronic health record (EHR) derived phenotypes (phecodes) and questionnaire data were used to examine the relationship between insomnia genetic liability and SUDs in BD. METHODS:...

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Identifiers

PMID: 40007167
DOI: 10.1111/bdi.70018
PMCID: PMC12256197

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