Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-ray induction of 6-thioguanine-resistant mutants in division arrested, G0/G1 phase Chinese hamster ovary cells.

Mutation research - 1 Jan 2000

O'Neill J P, Flint K B

Abstract excerpt

The cytotoxic and mutagenic effect of X-irradiation was determined with Chinese hamster ovary cells arrested in the G0/G1 phase of the cell cycle through 9 days incubation in serum-free medium. In comparison with exponential phase cultures, the arrested cells showed increased cytotoxicity and mutation induction over the dose range of 50-800 rad. Exponential cultures showed a linear mutant frequency-survival...

Topics

Animals
Cell Cycle
Cell Line
Cell Survival
Cricetinae
Cricetulus
Culture Media
Drug Resistance
Female
Hypoxanthine Phosphoribosyltransferase
Interphase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Thioguanine

X-Rays

Source

Identifiers

PMID: 4000168
DOI: 10.1016/0027-5107(85)90141-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-4000168-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-ray induction of 6-thioguanine-resistant mutants in division arrested, G0/G1 phase Chinese hamster ovary cells.PMID 4000168Read ↗

Mutation induction in haploid yeast after split-dose radiation exposure. II. Combination of UV-irradiation and X-rays.Semantic proximity Read ↗

Induction of chromosome aberrations in mammalian cells after heavy ion exposure.Semantic proximity Read ↗

Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant.Semantic proximity Read ↗

Cell cycle dependence for the induction of 6-thioguanine-resistant mutations: G2/M stage is distinctively sensitive to 252Cf neutrons but not to 60Co gamma-rays.Semantic proximity Read ↗

Cyclic X-Ray Responses in Mammalian Cells<i>in Vitro</i><sup>1</sup>Semantic proximity Read ↗

Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells.Semantic proximity Read ↗

DNA topoisomerase activities in Chinese hamster radiosensitive mutants after X-ray treatment.Semantic proximity Read ↗

Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells.Semantic proximity Read ↗

Sister-chromatid exchanges but not mutations decrease with time in arrested Chinese hamster ovary cells after treatment with ethylnitrosourea.Semantic proximity Read ↗

Cell cycle-dependent effects of wortmannin on radiation survival and mutation.Semantic proximity Read ↗

Response of X-ray-sensitive CHO mutant cells (xrs-6c) to radiation. II. Relationship between cell survival and the induction of chromosomal damage with low doses of alpha particles.Semantic proximity Read ↗

Differential response of human fibroblasts to the cytotoxic and mutagenic effects of UV radiation in different phases of the cell cycle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.