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Article

Cell cycle-dependent effects of wortmannin on radiation survival and mutation.

Radiation research - 1 Jun 2001

Chernikova S B, Lindquist K L, Elkind M M

Abstract excerpt

Wortmannin, a known radiation sensitizer, has been used in experiments with synchronized cells to compare its effect on radiation survival and mutation induction within the cell cycle. PL61 cells (CHO cells with an inactivated HPRT gene containing a single active copy of a bacterial gpt gene) were synchronized by mitotic selection. Wortmannin administered before gamma irradiation caused a greater sensitization in...

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PMID: 11352765
DOI: 10.1667/0033-7587(2001)155[0826:ccdeow]2.0.co;2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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