Article
DNA topoisomerase activities in Chinese hamster radiosensitive mutants after X-ray treatment.
Cell biology international - 1 Jan 2002
Pastor Nuria, Cortés Felipe
Abstract excerpt
In the last years the attractive hypothesis of a possible involvement of mammalian topoisomerases in DNA repair has been proposed, given their molecular mechanism of action. So far, using asynchronous cultures a lot of controversial results have been reported, without taking into account the frequently dramatic fluctuations of topoisomerase activities depending upon the cell cycle stage and proliferation rate...
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