Article
A coding single nucleotide polymorphism in the interleukin-6 receptor enhances IL-6 signalling in CD4 T cells and predicts treatment response to tocilizumab in giant cell arteritis.
Annals of the rheumatic diseases - 1 Aug 2025
Zorc Robert, Redmond Christopher, Sylvester McKella, Maclean Mary, Yamamoto de Almeida Luciana, Quinn Kaitlin A, Tomelleri Alessandro, Campochiaro Corrado, Dagna Lorenzo, Gutierrez-Rodrigues Fernanda, Wells Kristina V, Rankin Cameron, Hait Sabrina Helmold, Palmer Chloe, Corty Robert, Bick Alexander, Lambert Kathi, Buckner Jane H, O'Shea John J, Park Jin Kyun, Gadina Massimo, Grayson Peter C
Abstract excerpt
OBJECTIVES: The study objective was to determine if a common single nucleotide polymorphism in the interleukin 6 (IL-6) receptor (rs2228145, p.Asp358Ala) predicted treatment response to tocilizumab in giant cell arteritis (GCA). METHODS: Genetic sequencing of the rs2228145 locus was performed in 2 independent cohorts of patients with GCA. Peripheral blood mononuclear cells (PBMCs) from patients and controls were...
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