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Article

A single nucleotide polymorphism of IL6-receptor is associated with response to tocilizumab in rheumatoid arthritis patients.

The pharmacogenomics journal - 1 Aug 2019

Luxembourger Cécile, Ruyssen-Witrand Adeline, Ladhari Chayma, Rittore Cécile, Degboe Yannick, Maillefert Jean-Francis, Gaudin Philippe, Marotte Hubert, Wendling Daniel, Jorgensen Christian, Cantagrel Alain, Constantin Arnaud, Nigon Delphine, Touitou Isabelle, Gottenberg Jacques-Eric, Pers Yves-Marie

Abstract excerpt

Biological disease-modifying anti-rheumatic drugs (bDMARDs) have changed care of patients with rheumatoid arthritis (RA). However, bDMARDs are costly, can lead to serious infections, and induce a sustained remission in only 30% of RA patients. In this study, we sought to determine if the clinical response to treatment with Tocilizumab (TCZ), an IL-6 inhibitor, varied with genetic background. The efficacy of TCZ...

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Identifiers

PMID: 30647443
DOI: 10.1038/s41397-019-0072-6

Genes

IL6R
IL6

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