Article
Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study.
The Lancet. Rheumatology - 1 Jun 2024
Borrego-Yaniz Gonzalo, Ortiz-Fernández Lourdes, Madrid-Paredes Adela, Kerick Martin, Hernández-Rodríguez José, Mackie Sarah L, Vaglio Augusto, Castañeda Santos, Solans Roser, Mestre-Torres Jaume, Khalidi Nader, Langford Carol A, Ytterberg Steven, Beretta Lorenzo, Govoni Marcello, Emmi Giacomo, Cimmino Marco A, Witte Torsten, Neumann Thomas, Holle Julia, Schönau Verena, Pugnet Gregory, Papo Thomas, Haroche Julien, Mahr Alfred, Mouthon Luc, Molberg Øyvind, Diamantopoulos Andreas P, Voskuyl Alexandre, Daikeler Thomas, Berger Christoph T, Molloy Eamonn S, Blockmans Daniel, van Sleen Yannick, Iles Mark, Sorensen Louise, Luqmani Raashid, Reynolds Gary, Bukhari Marwan, Bhagat Shweta, Ortego-Centeno Norberto, Brouwer Elisabeth, Lamprecht Peter, Klapa Sebastian, Salvarani Carlo, Merkel Peter A, Cid María C, González-Gay Miguel A, Morgan Ann W, Martin Javier, Márquez Ana
Abstract excerpt
BACKGROUND: Giant cell arteritis is an age-related vasculitis that mainly affects the aorta and its branches in individuals aged 50 years and older. Current options for diagnosis and treatment are scarce, highlighting the need to better understand its underlying pathogenesis. Genome-wide association studies (GWAS) have emerged as a powerful tool for unravelling the pathogenic mechanisms involved in complex...
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