Article
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
The pharmacogenomics journal - 1 Jun 2013
Wang J, Bansal A T, Martin M, Germer S, Benayed R, Essioux L, Lee J S, Begovich A, Hemmings A, Kenwright A, Taylor K E, Upmanyu R, Cutler P, Harari O, Marchini J, Criswell L A, Platt Adam
Abstract excerpt
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease affecting the joints. A heterogeneous response to available therapies demonstrates the need to identify those patients likely to benefit from a particular therapy. Our objective was to identify genetic factors associated with response to tocilizumab, a humanized monoclonal antibody targeting the interleukin (IL)-6 receptor, recently approved for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.