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Loss of E-cadherin Activates EGFR-MEK/ERK Signaling, Promoting Cervical Cancer Progression

24 Feb 2025

Abstract excerpt

BACKGROUND/AIM: This study investigated the relationship between E-cadherin down-regulation and enhanced pERK1/2 signaling in cervical cancer, evaluated their combined prognostic impact, and explored potential therapeutic targets. MATERIALS AND METHODS: We analyzed 188 cervical cancer specimens and 300 normal cervical tissue samples using tissue microarray and immunohistochemistry. Small interfering RNA...

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PMID: 39993806
DOI: 10.21873/cgp.20501

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