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Article

PBK promotes aggressive phenotypes of cervical cancer through ERK/c-Myc signaling pathway.

Journal of cellular physiology - 1 Apr 2021

Ma Hanlin, Han Fang, Yan Xiaohui, Qi Gonghua, Li Yingwei, Li Rongrong, Yan Shi, Yuan Cunzhong, Song Kun, Kong Beihua

Abstract excerpt

Cervical cancer is the fourth most frequent cancer in women worldwide. PDZ-binding kinase (PBK) is proven to promote the malignant behaviors of various carcinomas. However, its functional roles and oncogenic mechanisms in cervical cancer are poorly understood. In this study, we reported that PBK was highly expressed in cervical cancer tissues. PBK promoted the proliferation, metastasis, and cisplatin resistance...

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PMID: 33184870
DOI: 10.1002/jcp.30134

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