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Article

A DLEU2/E2F1 regulatory axis promotes migration and invasion phenotypes in cervical squamous cell carcinoma.

Scientific reports - 6 May 2026

He Min, Huang Shiyi, Wang Mingjiang, Zhu Tangrui, Ding Jinhua, Wang Yitao, Liu Mingbo, Wen Hanlu

Abstract excerpt

Cervical squamous cell carcinoma (CSCC), the most prevalent form of cervical cancer, is often diagnosed at advanced stages with limited treatment efficacy. Cell migration and invasion are critical steps, yet its molecular mechanisms remain poorly understood. This study investigates the role of the long non‑coding RNA DLEU2 in CSCC migration and invasion. RNA sequencing of 7 invasive CSCC and 7 normal cervical...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Squamous Cell
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E2F1 Transcription Factor

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasm Invasiveness

Share to RNA, Long Noncoding

Share to Tumor Suppressor Proteins

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42091655
DOI: 10.1038/s41598-026-51939-4
PMCID: PMC13338257

Genes

E2F1
MMP9
SNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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