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Article

Mining bacterial genomes to reveal secret synergy

1 Dec 2018

Abstract excerpt

The medical treatment of infectious diseases often requires combination therapies that blend two molecules to enhance drug efficacy. Nature does the same. In a new article, Mrak et al. identify and functionally characterize natural products from Streptomyces rapamycinicus that show synergistic antifungal activity with the well-known immunosuppressant metabolite rapamycin, produced by the same strain. The genomic...

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PMID: 30593529
DOI: 10.1074/jbc.h118.006669

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