Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct mutant hepatitis B virus genomes, with alterations in all four open reading frames, in a single South African hepatocellular carcinoma patient.

Virus research - 1 Jan 2012

Skelton Michelle, Kew Michael C, Kramvis Anna

Abstract excerpt

Sequence variation of hepatitis B virus (HBV) can influence the replication, antigen expression and pathogenicity of the virus. We report on the mutational analysis of HBV performed in a 28-year-old Black South African female diagnosed with HBV-induced hepatocellular carcinoma. Full-genome amplification and DNA sequencing of HBV was carried out. Five distinct complete genomic clones were described with extensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Liver Neoplasms

Share to Mutagenesis, Insertional

Share to Open Reading Frames

Share to South Africa

Source

Identifiers

PMID: 21889961
DOI: 10.1016/j.virusres.2011.08.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct mutant hepatitis B virus genomes, with alterations in all four open reading frames, in a single South African hepatocellular carcinoma patient.PMID 21889961Read ↗

Molecular characterization of hepatitis B virus isolated from Black South African cancer patients, with and without hepatocellular carcinoma.Semantic proximity Read ↗

A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults.Semantic proximity Read ↗

Distinctive sequence characteristics of subgenotype A1 isolates of hepatitis B virus from South Africa.Semantic proximity Read ↗

Genotypic profiles of hepatitis B in African immigrants and their clinical relevance.Semantic proximity Read ↗

A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adultsSemantic proximity Read ↗

Analysis of the in vitro replication phenotype of African hepatitis B virus (HBV) genotypes and subgenotypes present in Australia identifies marked differences in DNA and protein expression.Semantic proximity Read ↗

Sequence variation upstream of precore translation initiation codon reduces hepatitis B virus e antigen production.Semantic proximity Read ↗

Characterization of occult hepatitis B virus strains in south african blood donors†Semantic proximity Read ↗

Molecular characterization of hepatitis B virus (HBV) in African children living in Australia identifies genotypes and variants associated with poor clinical outcome.Semantic proximity Read ↗

Full-length genomic analysis of hepatitis B virus isolates in a patient progressing from hepatitis to hepatocellular carcinoma.Semantic proximity Read ↗

Whole genome analysis of hepatitis B virus from four cases of fulminant hepatitis: genetic variability and its potential role in disease pathogenicity.Semantic proximity Read ↗

Complete genome analysis of hepatitis B virus in human immunodeficiency virus infected and uninfected South Africans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.