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Article

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC

1 Jul 2025

Abstract excerpt

Radiation resistance constitutes a formidable impediment in the treatment paradigm for hepatocellular carcinoma (HCC). Deubiquitinases (DUBs) exhibit notable efficacy in modulating cellular responses to stress and exogenous interventions, endowed with the critical trait of being targetable, thus facilitating the execution of precise therapeutic strategies. Here, we demonstrate that broad-spectrum inhibition of...

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Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to Ubiquitin and proteasome pathways

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PMID: 40595451
DOI: 10.1038/s41419-025-07807-6

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