Article
Estimating Gene Conversion Tract Length and Rate From PacBio HiFi Data.
Molecular biology and evolution - 3 Feb 2025
Charmouh Anders Poulsen, Porsborg Peter Sørud, Hansen Lasse Thorup, Besenbacher Søren, Boeg Winge Sofia, Almstrup Kristian, Hobolth Asger, Bataillon Thomas, Schierup Mikkel Heide
Abstract excerpt
Gene conversions are broadly defined as the transfer of genetic material from a "donor" to an "acceptor" sequence and can happen both in meiosis and mitosis. They are a subset of noncrossover (NCO) events and, like crossover (CO) events, gene conversion can generate new combinations of alleles and counteract mutation load by reverting germline mutations through GC-biased gene conversion. Estimating gene...
Read the complete abstract on PubMedTopics
- Gene Conversion
- Humans
- Polymorphism, Single Nucleotide
- Models, Genetic