Article

Roles of sex and SP-A genetic variants in modulating multiorgan injuries post viral infection

2026-08-21

Abstract excerpt

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), and multi-organ dysfunction (MOD). Human surfactant protein A (SP-A), a key component of innate immunity, exhibits genetic polymorphisms that may influence host responses to viral infection. Human patient studies have shown that biological sex has been as...

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Literature Corpus work: 3b357ab0-c4c9-54e8-9fa2-99cf828b1d4c
DOI: 10.3389/fimmu.2026.1866913

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