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PCNA in Pan-Cancer: A Prognostic Biomarker Unveiled Through a Data-Driven, Multidimensional Analysis of Transcriptomics, Immunity, and Functional Profiling

26 Jun 2025

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) is a central regulator of numerous cellular processes impacting DNA metabolism and genetic integrity, including DNA damage, cell cycle progression, and transcriptional regulation. PCNA aberrations manifest in different disease phenotypes, including neoplastic proliferation, chromatin disassembly, genomic instability, and impaired DNA repair. Although the role of PCNA in...

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PMID: 40657100
DOI: 10.1021/acsomega.5c03331

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