The influence of genetic variants of IL-6 (-174 G/C) and INFγ (+ 874 A/T) and their impact on anemic Sudanese children with kidney failure.

doi:10.1186/s13104-025-07095-5

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The influence of genetic variants of IL-6 (-174 G/C) and INFγ (+ 874 A/T) and their impact on anemic Sudanese children with kidney failure.

BMC research notes - 17 Feb 2025

Makkawi Abier Abdelaziz Makkawi Abdelrahman, GumaaElzaki Salah Eldin GumaaElzaki, Allam Nahla Allam, Mohammed Nadia Madani Mohammed Ahmed, Husain Nazik Elmalaika Obaid Seid Ahmed Husain

Abstract excerpt

OBJECTIVES: To investigate the influence of genetic variants IL-6 (-174 G/C) and interferon-gamma (IFNγ) (+ 874 A/T) on beta-globin gene expression, inflammation markers such as C-reactive protein (CRP), and their diagnostic impact on anemic Sudanese children with kidney failure. RESULTS: Severe and moderate anemia were observed in 88.9% of children aged 5-15 years. Semi-quantified molecular analysis of...

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Topics

Humans
Child
Interleukin-6
Anemia
Sudan
Interferon-gamma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adolescent

Male

Female

Child, Preschool

Renal Insufficiency

C-Reactive Protein

beta-Globins

Genotype

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39962550
DOI: 10.1186/s13104-025-07095-5
PMCID: PMC11831838

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