Interleukin gene polymorphisms (IL-6, IL-10, IL-17 a, IL-18) predict beta-thalassemia major susceptibility and inflammatory profiles in Iraqi children: A genetic risk score analysis.

Abstract excerpt

BACKGROUND: This research aims to evaluate the correlation between the four interleukin gene polymorphisms, namely (IL-6 -174 G/C, IL-10 -1082 A/G, IL-17 A -197 G/A, IL-18 -137 G/C), and the predisposition to develop beta-thalassemia major in Iraqi children, in addition to analyzing how these polymorphisms impact the serum cytokine levels. METHODS: This case-control study was conducted at the Thalassemia Center,...

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• beta-Thalassemia
• Inflammation
• Interleukin-10
• Interleukin-17
• Interleukin-18