Article
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation
2022-03-15
Abstract excerpt
<title>Abstract</title> <p>Increasing research has uncovered the involvement of long non-coding RNAs (lncRNAs) in the progression of multiple cancers including lung adenocarcinoma (LUAD). RT-qPCR and western blot were done to measure RNAs and proteins. Functional assays assessed LUAD cell biological behaviors under knockdown or overexpression of LINC01468, SIX5, SERBP1 or SERPINE1, and the specific function of th...
Topics
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- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
Identifiers and source
- Literature Corpus work
- 8bb2ff12-299d-5183-9522-3a2ea5aa9a2e
- DOI
- 10.21203/rs.3.rs-712175/v1
