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PGT-A Mosaicism Reporting Lacks Clinical Predictive Value: Evidence from a Multisite, Double-Blinded Study with Independent Validation Across 15,315 Single-Embryo Transfers

2025-06-24

Abstract excerpt

Preimplantation genetic testing for aneuploidy (PGT-A) aims to improve IVF outcomes by identifying embryos with lethal chromosomal abnormalities leading to impaired embryonic development and pregnancy loss, particularly with advancing maternal age. The adoption of next-generation sequencing (NGS) has enabled the detection of subtler chromosomal variations of uncertain clinical significance, such as intermediate co...

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Literature Corpus work
9b7e8bb2-2683-5470-aa58-3f68e5a71365
DOI
10.1101/2025.06.23.25329758
Open publication

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PGT-A Mosaicism Reporting Lacks Clinical Predictive Value: Evidence from a Multisite, Double-Blinded Study with Independent Validation Across 15,315 Single-Embryo TransfersDOI 10.1101/2025.06.23.25329758
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