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Article

Next-Generation Sequencing Is More Efficient at Detecting Mosaic Embryos and Improving Pregnancy Outcomes than Single-Nucleotide Polymorphism Array Analysis.

The Journal of molecular diagnostics : JMD - 1 Jun 2021

Xiao Min, Lei Cai-Xia, Xi Yan-Ping, Lu Yu-Lin, Wu Jun-Ping, Li Xiao-Yu, Zhang Shuo, Zhu Sai-Juan, Zhou Jing, Li Xiong, Zhang Yue-Ping, Sun Xiao-Xi

Abstract excerpt

We compared chromosomal mosaicism, detected by next-generation sequencing (NGS), during preimplantation genetic testing (PGT) with that detected by single-nucleotide polymorphism (SNP) array-based PGT to assess the pregnancy outcomes associated with both platforms in a retrospective cohort study of patients undergoing in vitro fertilization in a single university-based assisted reproduction center. In total, 6427...

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Embryo Transfer
Genetic Testing
High-Throughput Nucleotide Sequencing
Mosaicism
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy Outcome

Prenatal Screening and Diagnostics

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PMID: 33781963
DOI: 10.1016/j.jmoldx.2021.02.011

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