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Article

Immune Cell Distributions in the Blood of Healthy Individuals at High Genetic Risk of Parkinson's Disease.

International journal of molecular sciences - 20 Dec 2024

Deecke Laura, Goldeck David, Ohlei Olena, Homann Jan, Demuth Ilja, Bertram Lars, Pawelec Graham, Lill Christina M

Abstract excerpt

The immune system likely plays a key role in Parkinson's disease (PD) pathophysiology. Thus, we investigated whether immune cell compositions are already altered in healthy individuals at high genetic risk for PD. We quantified 92 immune cell subtypes in the blood of 442 individuals using multicolor flow cytometry. Polygenic risk scores (PGS) for PD were calculated based on genome-wide significant SNPs (n = 87)...

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Identifiers

PMID: 39769417
DOI: 10.3390/ijms252413655

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