α1-Antitrypsin Gene Variation Associates With Asthma Exacerbations and Related Health Care Utilization.

doi:10.1016/j.jaip.2025.01.039

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Article

α1-Antitrypsin Gene Variation Associates With Asthma Exacerbations and Related Health Care Utilization.

The journal of allergy and clinical immunology. In practice - 1 Jul 2025

Ortega Victor E, Tejwani Vickram, Shrivastav Abhishek Kumar, Pasha Sara, Zein Joe G, Boorgula Meher, Castro Mario, Denlinger Loren, Erzurum Serpil C, Fahy John V, Israel Elliot, Jarjour Nizar N, Levy Bruce, Mauger David, Moore Wendy C, Wenzel Sally E, Woodruff Prescott, Hawkins Gregory A, Bleecker Eugene R, Meyers Deborah A

Abstract excerpt

BACKGROUND: α1-Antitrypsin deficiency is caused by rare pathogenic variants in SERPINA1, the strongest genetic risk factor for chronic obstructive pulmonary disease. Few studies have evaluated the effects of SERPINA1 variation on asthma severity accounting for critical gene-by-environment interactions with smoking. OBJECTIVE: To characterize the influence of SERPINA1 variation on asthma severity. METHODS: DNA...

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Identifiers

PMID: 39954727
DOI: 10.1016/j.jaip.2025.01.039
PMCID: PMC13285010

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SERPINA1

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