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Article

Alpha-1 antitrypsin deficiency in bronchiectasis: Evidence for an overlooked entity beyond COPD: A retrospective observational study.

Medicine - 23 Jan 2026

Özdemir Levent, Pazarli Ahmet Cemal, Gegin Savaş, Özdemir Burcu, Aksu Esra Arslan, Çubukçu Mahcube

Abstract excerpt

Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant condition caused by mutations in the SERPINA1 gene. Chronic obstructive pulmonary disease/emphysema, asthma, and bronchiectasis are lung diseases associated with AATD. This study was designed to identify AATD in patients with bronchiectasis without emphysema and to demonstrate the frequency and distribution of AATD genotypes according to the type...

Topics

Humans
alpha 1-Antitrypsin Deficiency
Male
Bronchiectasis
Female
Retrospective Studies
Middle Aged
Aged
Adult
Pulmonary Disease, Chronic Obstructive
alpha 1-Antitrypsin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41578478
DOI: 10.1097/MD.0000000000047298
PMCID: PMC12851771

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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