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Article

Causal association between cerebral small vessel disease and epilepsy.

Neurosurgical review - 15 Feb 2025

Xu Qiwu, Tan Guoxiang, Zhao Yong, Ding Ting, Hu Ke, Ling Chen

Abstract excerpt

Cerebral small vessel disease (SVD) is known to increase the risk of epilepsy, but the causal relationship between the two remains unclear. This study utilizes Mendelian Randomization (MR) to assess the genetic link between SVD and epilepsy, incorporating additional analyses including colocalization, gene-set, and pathway analysis to provide further evidence for shared mechanisms. We performed a two-sample MR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39954159
DOI: 10.1007/s10143-025-03299-2

Genes

NOTCH3
PLEKHG1
ZNF646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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