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Generation of Retinal Pigment Epithelial Cells Derived from Human Embryonic Stem Cells Lacking Human Leukocyte Antigen Class I and II.

Stem cell reports - 14 Apr 2020

Petrus-Reurer Sandra, Winblad Nerges, Kumar Pankaj, Gorchs Laia, Chrobok Michael, Wagner Arnika Kathleen, Bartuma Hammurabi, Lardner Emma, Aronsson Monica, Plaza Reyes Álvaro, André Helder, Alici Evren, Kaipe Helen, Kvanta Anders, Lanner Fredrik

Abstract excerpt

Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells could serve as a replacement therapy in advanced stages of age-related macular degeneration. However, allogenic hESC-RPE transplants trigger immune rejection, supporting a strategy to evade their immune recognition. We established single-knockout beta-2 microglobulin (SKO-B2M), class II major histocompatibility complex transactivator...

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Identifiers

PMID: 32197113
DOI: 10.1016/j.stemcr.2020.02.006
PMCID: PMC7160308

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