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Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas

25 Mar 2021

Abstract excerpt

ESC- and iPSC-derived retinal transplantation is a promising therapeutic approach for disease with end-stage retinal degeneration, such as retinitis pigmentosa and age-related macular degeneration. We previously showed medium- to long-term survival, maturation, and light response of transplanted human ESC- and iPSC-retina in mouse, rat, and monkey models of end-stage retinal degeneration. Because the use of...

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PMID: 33770500
DOI: 10.1016/j.stemcr.2021.02.021

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