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Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing

18 Jan 2022

Abstract excerpt

Significance HIV-1 infection requires lifelong treatment with antiretroviral therapy (ART) due to viral rebound of a latent reservoir of intact, transcriptionally silent provirus found to persist in the genome of CD4 + T cells. One major challenge to understanding the nature of the latent reservoir is accurately characterizing the measuring of the size of the reservoir. Herein, we use quadruplex polymerase chain...

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PMID: 35042816
DOI: 10.1073/pnas.2117630119

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