Article
Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants.
Journal of the American Heart Association - 18 Feb 2025
Iyer Kruthika R, Clarke Shoa L, Guarischi-Sousa Rodrigo, Gjoni Ketrin, Heath Adam S, Young Erica P, Stitziel Nathan O, Laurie Cecelia, Broome Jai G, Khan Alyna T, Lewis Joshua P, Xu Huichun, Montasser May E, Ashley Kellan E, Hasbani Natalie R, Boerwinkle Eric, Morrison Alanna C, Chami Nathalie, Do Ron, Rocheleau Ghislain, Lloyd-Jones Donald M, Lemaitre Rozenn N, Bis Joshua C, Floyd James S, Kinney Gregory L, Bowden Donald W, Palmer Nicholette D, Benjamin Emelia J, Nayor Matthew, Yanek Lisa R, Kral Brian G, Becker Lewis C, Kardia Sharon L R, Smith Jennifer A, Bielak Lawrence F, Norwood Arnita F, Min Yuan-I, Carson April P, Post Wendy S, Rich Stephen S, Herrington David, Guo Xiuqing, Taylor Kent D, Manson JoAnn E, Franceschini Nora, Pollard Katherine S, Mitchell Braxton D, Loos Ruth J F, Fornage Myriam, Hou Lifang, Psaty Bruce M, Young Kendra A, Regan Elizabeth A, Freedman Barry I, Vasan Ramachandran S, Levy Daniel, Mathias Rasika A, Peyser Patricia A, Raffield Laura M, Kooperberg Charles, Reiner Alex P, Rotter Jerome I, Jun Goo, de Vries Paul S, Assimes Themistocles L
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics of CAD, the contribution of structural variants (SVs) to the risk of CAD remains largely unclear. METHOD AND RESULTS: We leveraged SVs detected...
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