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Article

Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model.

Frontiers in immunology - 1 Jan 2024

Hornikova Tereza, Jelinkova Anna, Jiraskova Zakostelska Zuzana, Thon Tomas, Coufal Stepan, Polouckova Andrea, Kopelentova Eliska, Kverka Miloslav, Makovicky Peter, Tlaskalova-Hogenova Helena, Sediva Anna, Schwarzer Martin, Srutkova Dagmar

Abstract excerpt

Background: The dual allergen exposure hypothesis states that sensitization to food antigens occurs through a damaged skin barrier in individuals with no previous oral tolerance to certain foods. However, the resulting allergic reaction could depend on factors such as the host's genetic predisposition as well as the skin and gut microbiota. Methods: Specific-pathogen-free BALB/c and C57BL/6 and germ-free (GF)...

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Allergens
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Food Hypersensitivity
Gastrointestinal Microbiome

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PMID: 39944558
DOI: 10.3389/fimmu.2024.1509691
PMCID: PMC11814220

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