Article
Epigenetic phenotype of plasma cell-free DNA in the prediction of early-onset preeclampsia.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology - 1 Dec 2023
He Wei, Zhang Yi, Wu Kai, Wang Yunan, Zhao Xin, Lv Lijuan, Ren Congmian, Lu Jiaqi, Yang Jiexia, Yin Aihua, Liu Guocheng
Abstract excerpt
BACKGROUND: In the current study, we sought to characterise the methylation haplotypes and nucleosome positioning patterns of placental DNA and plasma cell-free DNA of pregnant women with early-onset preeclampsia using whole genome bisulphite sequencing (WGBS) and methylation capture bisulphite sequencing (MCBS) and further develop and examine the diagnostic performance of a generalised linear model (GLM) by...
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