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Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study

15 Apr 2025

Abstract excerpt

BACKGROUND: Preterm birth (PTB) occurs in approximately 11% of all births worldwide, resulting in significant morbidity and mortality for both mothers and their offspring. Identifying pregnancies at risk of preterm birth during early pregnancy may help improve interventions and reduce its incidence. Plasma cell-free DNA (cfDNA), derived from placenta and other maternal tissues, serves as a dynamic indicator of...

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Share to Prenatal Screening and Diagnostics
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PMID: 40233080
DOI: 10.1371/journal.pmed.1004571

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