Article
Replication and heritability of prostate cancer risk variants: impact of population-specific factors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2015
Virlogeux Victor, Graff Rebecca E, Hoffmann Thomas J, Witte John S
Abstract excerpt
BACKGROUND: Prostate cancer incidence and mortality rates vary across populations, with African American men exhibiting the highest rates. To date, genome-wide association studies have identified 104 SNPs independently associated with prostate cancer in men of European ancestry. METHODS: We investigated whether the ability to replicate findings for these 104 SNPs in African American, Asian, and Latino populations...
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