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Article

The role of protective genetic variants in modulating epigenetic aging.

GeroScience - 1 Aug 2025

Bejaoui Yosra, Srour Luma, Qannan Abeer, Oshima Junko, Saad Chadi, Horvath Steve, Mbarek Hamdi, El Hajj Nady

Abstract excerpt

Several progeroid syndromes' causative mutations have been linked to epigenetic age acceleration as measured via several epigenetic clocks. At the same time, several protective variants have also been discovered that can reduce the risk of developing certain age-related disorders. However, the impact of these protective variants on epigenetic aging has not been well elucidated. Our research, which involved...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39928272
DOI: 10.1007/s11357-025-01548-2
PMCID: PMC12397041

Genes

APOE
PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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