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Article

Recombinant vector vaccine evolution

19 Jul 2019

Abstract excerpt

Replicating recombinant vector vaccines consist of a fully competent viral vector backbone engineered to express an antigen from a foreign transgene. From the perspective of viral replication, the transgene is not only dispensable but may even be detrimental. Thus vaccine revertants that delete or inactivate the transgene may evolve to dominate the vaccine virus population both during the process of manufacture...

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PMID: 31323032
DOI: 10.1371/journal.pcbi.1006857

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