Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer

6 Feb 2025

Abstract excerpt

Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR-dependent luminal epithelial cell identity. Tumors progress during therapy to castration-resistant prostate cancer (CRPC) by restoring AR signaling and maintaining luminal identity or by converting through lineage plasticity to a neuroendocrine (NE) identity or double-negative CRPC (DNPC) lacking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostate Cancer Treatment and Research

Source

Identifiers

PMID: 39913208
DOI: 10.1073/pnas.2415308122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancerPMID 39913208Read ↗

Basal epithelial cells in prostate development, tumorigenesis, and cancer progressionSemantic proximity Read ↗

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cellsSemantic proximity Read ↗

Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancerSemantic proximity Read ↗

A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasisSemantic proximity Read ↗

The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approachesSemantic proximity Read ↗

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilitiesSemantic proximity Read ↗

Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancerSemantic proximity Read ↗

Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.Semantic proximity Read ↗

A transition zone enriched <i>WIF1</i> ⁺ basal cell subtype is associated with benign prostatic hyperplasiaSemantic proximity Read ↗

Cellular cartography reveals mouse prostate organization and determinants of castration resistanceSemantic proximity Read ↗

Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progressionSemantic proximity Read ↗

Defining the combinatorial nature of gene modules in prostate cancer underlying lineage plasticity and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.