Article
Comparison of Two Genotyping Methods for Distinguishing Recrudescence from Reinfection in Antimalarial Drug Efficacy/Effectiveness Trials.
The American journal of tropical medicine and hygiene - 1 Jul 2018
Fulakeza Joseph R M, Banda Rachel L, Lipenga Trancizeo R, Terlouw Dianne J, Nkhoma Standwell C, Hodel Eva Maria
Abstract excerpt
Genotyping of allelic variants of Plasmodium falciparum merozoite surface proteins 1 and 2 (msp-1 and msp-2), and the glutamate-rich protein is the gold standard for distinguishing reinfections from recrudescences in antimalarial drug trials. We compared performance of the recently developed 24-s...
Topics
- Antigens, Protozoan
- Antimalarials
- Artemether, Lumefantrine Drug Combination
- Artemisinins
- Child
- Cluster Analysis
- Drug Combinations
- Female
- Gene Expression
- Genotype
- Genotyping Techniques
- Humans
- Malaria, Falciparum
- Malawi
- Male