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Article

Comparison of Two Genotyping Methods for Distinguishing Recrudescence from Reinfection in Antimalarial Drug Efficacy/Effectiveness Trials.

The American journal of tropical medicine and hygiene - 1 Jul 2018

Fulakeza Joseph R M, Banda Rachel L, Lipenga Trancizeo R, Terlouw Dianne J, Nkhoma Standwell C, Hodel Eva Maria

Abstract excerpt

Genotyping of allelic variants of Plasmodium falciparum merozoite surface proteins 1 and 2 (msp-1 and msp-2), and the glutamate-rich protein is the gold standard for distinguishing reinfections from recrudescences in antimalarial drug trials. We compared performance of the recently developed 24-single-nucleotide polymorphism (SNP) Barcoding Assay against msp-1 and msp-2 genotyping in a cluster-randomized...

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Identifiers

PMID: 29785925
DOI: 10.4269/ajtmh.18-0002
PMCID: PMC6085787

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Source receipt: pubmed, retrieved 7 Sept 2026.

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