Article
Microsatellites reveal high polymorphism and high potential for use in anti-malarial efficacy studies in areas with different transmission intensities in mainland Tanzania.
Malaria journal - 15 Mar 2024
Ishengoma Deus S, Mandara Celine I, Madebe Rashid A, Warsame Marian, Ngasala Billy, Kabanywanyi Abdunoor M, Mahende Muhidin K, Kamugisha Erasmus, Kavishe Reginald A, Muro Florida, Mandike Renata, Mkude Sigsbert, Chacky Frank, Njau Ritha, Martin Troy, Mohamed Ally, Bailey Jeffrey A, Fola Abebe A
Abstract excerpt
BACKGROUND: Tanzania is currently implementing therapeutic efficacy studies (TES) in areas of varying malaria transmission intensities as per the World Health Organization (WHO) recommendations. In TES, distinguishing reinfection from recrudescence is critical for the determination of anti-malarial efficacy. Recently, the WHO recommended genotyping polymorphic coding genes, merozoite surface proteins 1 and 2...
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